The Milken Institute’s annual Best-Performing Cities (BPC) rankings provide an objective framework for evaluating the relative performance of US cities. Despite the impact of COVID-19, US cities continue to serve as the primary hubs of economic activity. The rankings for this year are primarily based on 2021 data, offering an assessment of cities' performance amidst the rapidly changing social, demographic, and economic landscape following the initial year of the pandemic. Along with the